Universitat Rovira i Virgili
Nutrition and Metabolism
Effect of a mediterranean diet on changes in gut microbiota and epigenetic tags.
Fighting overweight and obesity is one of the greatest challenges of the 21stcentury because is a major risk factor for other metabolic diseases including type 2 diabetes and cardiovascular disease. Therefore, a better knowledge of mechanisms common to metabolic disorders together with the design of effective strategies able to modify these mechanisms towards a healthier function are mandatory in order to decrease the burden of metabolic diseases.
Objective. The Project will investigate whether following a Mediterranean Diet modifies gut microbial composition and epigenetics (miRNA, telomere lenght, DNA methylation) thereby reducing metabolic risk factors as a potential mechanism explaining the link between gut mircrobiota and obseity-related comorbidities. The study will be conducted on overweigt/obese metabolic participants followed by 3 months. Gut microbiota richness and composition will be evaluated. Circulating metabolomics and fecal metabolomic profiling will be analysed using three different platforms: Proton nuclear magnetic resonance (1H NMR), liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS). Telomere lenght, total DNA methylation and methylation in specific genes related to inflammation will also be analysed.
37.5 hours a week
|This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 713679|